RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury

Blog Article

Therapeutic hypothermia is a potent tool in the treatment of neonatal pedal arm pivot hypoxic-ischemic (HI) injury, yet the underlying mechanisms remain unclear.Here, authors demonstrate how the RNA-binding motif protein RBM3, which is induced by mild cooling while global translation rate is slowed down, contributes substantially to neuroregeneration after adult HI injury, specifically in the subventricular zone Flask and subgranular zone.